APPIFISH: Antibiotic resistance Pathogenicity Infectiology in fish

Context and Issues

• Importance of bacterial infectious diseases in aquaculture
• Ecoantibio 1 & 2 Plan: Willingness to reduce medicinal inputs by 25%

Objectives

• A better understanding of the genetic and phenotypic variability of isolated pathogenic bacteria in fish farms,
• A better understanding of the persistence of the infectious agent in livestock by identifying potential reservoirs,
• A better understanding of the immune interactions between the pathogen and its host.

The final objective is to better understand the control strategies of two bacteria Yersinia ruckeri and Flavobacterium psychrophilum by developing prophylactic means and limiting the use of antibiotic-type inputs.

Target species

Fish pathology bacteria

• Yersinia ruckeri
• Aeromonas spp.
• Flavobacterium psychrophilum

Application fields

• Aquaculture (rainbow trout)
• Bacterial diseases of farming fishes
• Antimicrobial-resistance
• Bacterial genetic variability

Expertise and skills

• Bacteriology
• Physiopathology
• Immunology
• Epidemiology
• Pharmacology

Projets en cours

• Enr-EAU-bage: Creation of a guide to good practice adapted to the coating of feed with antibiotics on fish farms
• EPIRESIST-METHLYR: Epigenome of bacteria isolated from fish farming and its evolution during prolonged exposure to non-antibiotic chemical contaminants
• MARCOPOLO: MAcRobraChium Opportunités Pays de la LOire
• Pour-SANG-tage: Establishment of a set of standards for the taking of blood samples from salmonids in animal experiments
• VacEasy: To promote vaccination in fish farms by evaluating vaccine protocols that improve technical feasibility

Team members

Researchers :

• Ségolène Calvez (MC DGER, Resp. Équipe)
• Emmanuelle Moreau (PR DGER)
• Nora Navarro-Gonzalez (MC)
• Kenny Oberlé (MC)
• Hervé Pouliquen (PR)
• Antoine Rostang (MC)

Technical and scientific support

• Céline David (TR)
• Lionel Pineau (TR)

PhD & post-doc

• Houssem Ben Yahia (PostDoc)